(1452-1519)
- Adoration of the Magi – 1481-82 (Panel)
- Annunciation – c.1472-75 (Oil on panel)
- Baptism of Christ – c.1472-73 (Tempera and oil on panel)
- Battle of Anghiari – ???? (Panel)
- Benois Madonna – c.1478 (Oil on canvas)
- Ginevra de’ Benci – c.1474 (Oil on panel)
- Lady with the Ermine – c.1483-86 (Oil on panel)
- Last Supper – 1495-97 (Oil tempera mixture on wall)
- Madonna Litta – c.1490 (Tempera on canvas)
- Madonna of the Rocks – c.1485 (Tempera on panel)
- Mona Lisa – c.1503 (Oil on panel)
- Portrait of a Woman – c.1490 (Oil on panel)
- Portrait of Isabella d’Este – ???? (Black chalk with charcoal with pastel)
- Saint Jerome – c.1482 (Panel)
- Saint John the Baptist – c.1513-16 (Oil on panel)
- Self-Portrait – c.1512-15 (Red chalk)
- Storm Breaking over a Valley – c.1499 (Red chalk on white paper)
- Virgin and Child with Sainte Anne – 1499-1501 (Charcoal heightened with white, on brown paper)